Lipids and thyroid hormones.

C O N T E N T S ABBREVIATIONS I. Tin,on3 HORMONE MECHANISMS A. Calorigenic and anabolic effects B. Thyroid hormone entry into cells II. LIPID METAeOLISM A. Cell lipid composition B. Fatty acid synthesis 1. Protein phosphorylation-dephosphorylation 2. Gene expression C. NADPH generation and oxidation 1. Cytoplasm: NADP+--*NADPH 2. Mitochondria: NADP + + NADH,NADPH + NAD + 3. Microsomes: NADPH-*NADP + D. Fatty acid activation E. Glycerolipid synthesis F. Lipolysis G. Ketogenesis H. Cholesterol metabolism I. Intracellular cholesterol metabolism 2. Cholesterol transport I. Fatty acid desaturation 1. Anuran metamorphosis J. Fatty acid oxidation K. Prostanoid synthesis L. Sulfolipid synthesis M. Summary III. CELL MEMBRANE AND ASSOCIATED SYSTEMS A. Lipid composition and physical properties B. cAMP synthesis and hydrolysis I. Adenylate cyclase 2. Cyclic nucleotide phosphodiesterases C. Ca2+-ATPases D. Na+K+-ATPase E. Plasma Membrane Permeability 1. Na +, K+-Cotransporters 2. Na+-H + Antiporter IV. MITOCHONDRIAL OXIDATIVE PHO6PHORYLATION A. State 4 respiration in liver mitochondria B. State 3 respiration in liver mitochondria 1. ADP/ATP carrier 2. Substrate carriers 3. Cytochrome bc~ segment 4. Cytochrome oxidase 5. P, transporter 6. Substrate dehydrogenases 7. ATP-synthetase 8. Ca2+-transporter 9. Pyridine nucleotide transhydrogenase 10. Repetitive additions of ADP C. Liver mitochondria of fetal and neonatal rats D. Heart and brain mitochondria E. Essential fatty acid deficiency V. PEP.SPECTIVE ACKNOWLEI~Emwrs RW'V.~NC~S 199 200 200 201 202 202 205 206 208 210 210 211 211 211 213 216 217 217 217 220 221 223 224 227 227 227 228 228 229 229 232 233 235 239 239 240 241 245 248 249 250 250 251 251 251 252 252 253 254 254 255 257 259 259 259